Non-coding RNAs in pancreatic ductal adenocarcinoma: New approaches for better diagnosis and therapy

Maria Mortoglou; Zoey Kathleen Tabin; E Damla Arisan; Hemant M Kocher; Pinar Uysal-Onganer

doi:10.1016/j.tranon.2021.101090

Non-coding RNAs in pancreatic ductal adenocarcinoma: New approaches for better diagnosis and therapy

Transl Oncol. 2021 Jul;14(7):101090. doi: 10.1016/j.tranon.2021.101090. Epub 2021 Apr 5.

Authors

Maria Mortoglou¹, Zoey Kathleen Tabin², E Damla Arisan³, Hemant M Kocher⁴, Pinar Uysal-Onganer⁵

Affiliations

¹ Cancer Research Group, School of Life Sciences, University of Westminster, London W1W 6UW, UK. Electronic address: w1754188@my.westminster.ac.uk.
² Cancer Research Group, School of Life Sciences, University of Westminster, London W1W 6UW, UK. Electronic address: zoey.tabin@icloud.com.
³ Institution of Biotechnology, Gebze Technical University, Gebze, Turkey. Electronic address: damlaarisan@gmail.com.
⁴ Centre for Tumour Biology, Barts Cancer Institute-a CRUK Centre of Excellence, Queen Mary University London, London EC1M 6BQ, UK. Electronic address: h.kocher@qmul.ac.uk.
⁵ Cancer Research Group, School of Life Sciences, University of Westminster, London W1W 6UW, UK. Electronic address: p.onganer@westminster.ac.uk.

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies with a 5-year survival rate less than 8%, which has remained unchanged over the last 50 years. Early detection is particularly difficult due to the lack of disease-specific symptoms and a reliable biomarker. Multimodality treatment including chemotherapy, radiotherapy (used sparingly) and surgery has become the standard of care for patients with PDAC. Carbohydrate antigen 19-9 (CA 19-9) is the most common diagnostic biomarker; however, it is not specific enough especially for asymptomatic patients. Non-coding RNAs are often deregulated in human malignancies and shown to be involved in cancer-related mechanisms such as cell growth, differentiation, and cell death. Several micro, long non-coding and circular RNAs have been reported to date which are involved in PDAC. Aim of this review is to discuss the roles and functions of non-coding RNAs in diagnosis and treatments of PDAC.

Keywords: Circular RNA; Long non-coding RNA; MicroRNA; Non-coding RNAs; Pancreatic ductal adenocarcinoma.

Publication types

Review