An NAD+/NMN balancing act by SARM1 and NMNAT2 controls axonal degeneration

Thomas J Waller; Catherine A Collins

doi:10.1016/j.neuron.2021.03.021

An NAD+/NMN balancing act by SARM1 and NMNAT2 controls axonal degeneration

Neuron. 2021 Apr 7;109(7):1067-1069. doi: 10.1016/j.neuron.2021.03.021.

Authors

Thomas J Waller¹, Catherine A Collins²

Affiliations

¹ Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109-1085, USA.
² Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109-1085, USA. Electronic address: collinca@umich.edu.

PMID: 33831359
DOI: 10.1016/j.neuron.2021.03.021

Abstract

Axonal degeneration is controlled by the TIR domain NADase SARM1. In this issue of Neuron, Figley et al. (2021) reveal a key regulatory mechanism that controls SARM1's enzymatic activity, providing insight into how NAD+ biosynthesis by the NMNAT2 enzyme protects axons, and a new therapeutic path to tune SARM1 activity.

Publication types

Comment

MeSH terms

Armadillo Domain Proteins* / genetics
Axons
Cytoskeletal Proteins / genetics
NAD*
NAD+ Nucleosidase

Substances

Armadillo Domain Proteins
Cytoskeletal Proteins
NAD
NAD+ Nucleosidase

Abstract

Publication types

MeSH terms

Substances

Grants and funding