Sudden Cardiac Death-A New Insight Into Potentially Fatal Genetic Markers

Dragan Primorac; Ljubica Odak; Vitorio Perić; Jasmina Ćatić; Jozica Šikić; Vjekoslav Radeljić; Šime Manola; Robert Nussbaum; Matteo Vatta; Swaroop Aradhya; Tanja Sofrenović; Vid Matišić; Vilim Molnar; Andrea Skelin; Jure Mirat; Johannes Brachmann

doi:10.3389/fmed.2021.647412

Sudden Cardiac Death-A New Insight Into Potentially Fatal Genetic Markers

Front Med (Lausanne). 2021 Mar 22:8:647412. doi: 10.3389/fmed.2021.647412. eCollection 2021.

Authors

Dragan Primorac^{1

2

3

4

5

6

7

8

9}, Ljubica Odak^{1

10}, Vitorio Perić¹, Jasmina Ćatić^{1

11}, Jozica Šikić¹², Vjekoslav Radeljić¹³, Šime Manola¹³, Robert Nussbaum¹⁴, Matteo Vatta¹⁴, Swaroop Aradhya¹⁴, Tanja Sofrenović¹⁴, Vid Matišić¹, Vilim Molnar¹, Andrea Skelin¹, Jure Mirat⁶, Johannes Brachmann^{4

8}

Affiliations

¹ St. Catherine Specialty Hospital, Zagreb, Croatia.
² Eberly College of Science, The Pennsylvania State University, University Park, State College, Philadelphia, PA, United States.
³ The Henry C. Lee College of Criminal Justice and Forensic Sciences, University of New Haven, West Haven, CT, United States.
⁴ Medical School, University of Split, Split, Croatia.
⁵ Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
⁶ Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
⁷ Medical School, University of Rijeka, Rijeka, Croatia.
⁸ Medical School REGIOMED, Coburg, Germany.
⁹ Medical School, University of Mostar, Mostar, Bosnia and Herzegovina.
¹⁰ Children's Hospital Zagreb, Zagreb, Croatia.
¹¹ Department of Cardiology, Clinical Hospital Dubrava, Zagreb, Croatia.
¹² Department of Cardiology, Clinical Hospital Sveti Duh, Zagreb, Croatia.
¹³ Department of Cardiology, Clinical Hospital Center Sestre Milosrdnice, Zagreb, Croatia.
¹⁴ Invitae, San Francisco, CA, United States.

Abstract

Sudden cardiac death (SCD) is an unexpected and dramatic event. It draws special attention especially in young, seemingly healthy athletes. Our scientific paper is based on the death of a young, 23-year-old professional footballer, who died on the football field after a two-year history of cardiac symptoms. In this study we analyzed clinical, ECG and laboratory data, as well as results of genetic testing analysis in family members. To elucidate potential genetic etiology of SCD in this family, our analysis included 294 genes related to various cardiac conditions.

Keywords: cardiomyopathy; coronary artery disease; genes; professional athletes; sudden cardiac death.