Abnormal Elevation of Anti-Mullerian Hormone and Androgen Levels Presenting as Granulosa Cell Tumor

Hongbin Chi; Ning Huang; Huamao Liang; Rong Li; Congrong Liu; Jie Qiao

doi:10.3389/fonc.2021.641166

Abnormal Elevation of Anti-Mullerian Hormone and Androgen Levels Presenting as Granulosa Cell Tumor

Front Oncol. 2021 Mar 22:11:641166. doi: 10.3389/fonc.2021.641166. eCollection 2021.

Authors

Hongbin Chi¹, Ning Huang¹, Huamao Liang², Rong Li¹, Congrong Liu³, Jie Qiao¹

Affiliations

¹ Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
² Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
³ Department of Pathology, Peking University Third Hospital, Beijing, China.

Abstract

We report a rare subtype of adult cystic granulosa cell tumor (AGCT) characterized by elevated anti-Mullerian hormone and hyperandrogenism. A 35-year-old woman with primary infertility, hyperandrogenism, and irregular menses who was previously diagnosed with polycystic ovarian syndrome was diagnosed with AGCT based on histopathological examination and FOXL2 genetic test after laparoscopy. Due to fertility aspirations, she underwent controlled ovarian stimulation followed by embryo cryopreservation before salpingo-oophorectomy, and two embryos were frozen-thawed and transferred after surgery. A healthy female infant was delivered at 40 weeks' gestation. Cystic granulosa cell tumors should be considered a differential diagnosis in patients with persistent ovarian cysts and hyperandrogenism. Younger patients with AGCT with fertility goals should consider active assisted reproduction measures to preserve fertility before treatment for AGCT.

Keywords: anti-Mullerian hormone; granulosa cell tumor; hyperandrogenism; infertility; ovarian cyst.