In Vitro, In Vivo and Ex Vivo Models for Peripheral Nerve Injury and Regeneration

Andrew Li; Clifford Pereira; Elise Eleanor Hill; Olivia Vukcevich; Aijun Wang

doi:10.2174/1570159X19666210407155543

In Vitro, In Vivo and Ex Vivo Models for Peripheral Nerve Injury and Regeneration

Curr Neuropharmacol. 2022;20(2):344-361. doi: 10.2174/1570159X19666210407155543.

Authors

Andrew Li¹, Clifford Pereira¹, Elise Eleanor Hill², Olivia Vukcevich³, Aijun Wang^{2

3

4

5}

Affiliations

¹ Hand and Microsurgery, Division of Plastic Surgery, Department of Surgery, School of Medicine, University of California Davis, Sacramento, California, USA.
² Department of Surgery, School of Medicine, University of California Davis, Sacramento, California, USA.
³ Department of Surgery, Surgical Bioengineering Laboratory, School of Medicine, University of California Davis, Sacamento, California, USA.
⁴ Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children, Sacramento, California, USA.
⁵ Department of Biomedical Engineering, University of California Davis, Davis, California, USA.

Abstract

Peripheral Nerve Injuries (PNI) frequently occur secondary to traumatic injuries. Recovery from these injuries can be expectedly poor, especially in proximal injuries. In order to study and improve peripheral nerve regeneration, scientists rely on peripheral nerve models to identify and test therapeutic interventions. In this review, we discuss the best described and most commonly used peripheral nerve models that scientists have and continue to use to study peripheral nerve physiology and function.

Keywords: Ex vivo models; in vitro models; in vivo models; organotypic models; peripheral nerve; peripheral nerve injury; peripheral nerve regeneration.

In Vitro, In Vivo and Ex Vivo Models for Peripheral Nerve Injury and Regeneration

Authors

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Abstract

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