Fundic Gland Polyp With Parietal Cell Vacuolation Mimicking Signet Ring Cell Carcinoma

Int J Surg Pathol. 2021 Aug;29(5):503-505. doi: 10.1177/1066896921994183. Epub 2021 Apr 7.

Abstract

Pseudo-signet ring parietal cell vacuolation has been described as a mimic of invasive signet ring cell carcinoma. Moreover, signet ring cell carcinoma has been described in a fundic gland polyp. This case demonstrates parietal cell vacuolation in a fundic gland polyp in a patient on a long-term proton pump inhibitor.

Keywords: fundic gland polyp; pseudo-signet ring cells; vacuolation.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Biopsy
  • Carcinoma, Signet Ring Cell / diagnosis*
  • Diagnosis, Differential
  • Gastric Fundus / diagnostic imaging
  • Gastric Fundus / drug effects
  • Gastric Fundus / pathology*
  • Gastritis / drug therapy
  • Gastroscopy
  • Humans
  • Male
  • Polyps / chemically induced
  • Polyps / diagnosis*
  • Proton Pump Inhibitors / adverse effects
  • Stomach Neoplasms / chemically induced
  • Stomach Neoplasms / diagnosis*

Substances

  • Proton Pump Inhibitors

Supplementary concepts

  • Polyposis Of Gastric Fundus Without Polyposis Coli