ADAMTS9-AS2: A Functional Long Non-coding RNA in Tumorigenesis

Curr Pharm Des. 2021;27(23):2722-2727. doi: 10.2174/1381612827666210325105106.

Abstract

Background: Long non-coding RNAs (lncRNA) have been identified as novel molecular regulators in cancers. LncRNA ADAMTS9-AS2 can mediate the occurrence and development of cancer through various ways, such as regulating miRNAs, activating the classical signaling pathways in cancer, and so on, which have been studied by many scholars. In this review, we summarize the molecular mechanisms of ADAMTS9-AS2 in different human cancers.

Methods: Through a systematic search of PubMed, lncRNA ADAMTS9-AS2 mediated molecular mechanisms in cancer are summarized inductively.

Results: ADAMTS9-AS2 aberrantly expression in different cancers is closely related to cancer proliferation, invasion, migration, and inhibition of apoptosis. The involvement of ADAMTS9-AS2 in DNA methylation, mediating PI3K / Akt / mTOR signaling pathways, and regulating miRNAs and proteins, shows its significant potential as a therapeutic cancer target.

Conclusion: LncRNA ADAMTS9-AS2 can become a promising biomolecular marker and a therapeutic target for human cancer.

Keywords: ADAMTS9-AS2; DNA methylation; Long non-coding RNA; malignant tumors; mediating PI3K.; therapeutic targets.

Publication types

  • Review

MeSH terms

  • ADAMTS9 Protein / genetics
  • Cell Line, Tumor
  • Cell Movement
  • Cell Proliferation / genetics
  • Cell Transformation, Neoplastic*
  • Gene Expression Regulation, Neoplastic
  • Humans
  • MicroRNAs* / genetics
  • RNA, Long Noncoding* / genetics

Substances

  • MicroRNAs
  • RNA, Long Noncoding
  • ADAMTS9 Protein
  • ADAMTS9 protein, human