Tumor microenvironment (TME) is a dynamic network distributed around tumor cells. Cancer-associated fibroblasts (CAFs), as an important component of the TME, are not only closely related to normal fibroblasts, but also can secrete a variety of substances to participate in the regulation of the TME. Exosomes, one of the substances from CAFs, can promote the formation and development of lung cancer, including promoting the formation of TME, increasing pulmonary tumor cell invasion and metastasis, mediating pulmonary tumor immunosuppression and participating in radiotherapy and chemotherapy resistance. This article reviews the current research status and progress of cancer associated fibroblasts-derived exosomes in lung cancer. .
【中文题目：癌相关成纤维细胞来源的外泌体 在肺恶性肿瘤中的研究进展】 【中文摘要：肿瘤微环境（tumor microenvironment, TME）是分布在肿瘤细胞周围的动态网络，癌相关成纤维细胞（cancer-associated fibroblasts, CAFs）作为肿瘤微环境中的一部分，不但与正常成纤维细胞密切相关，而且可以分泌多种物质（包括外泌体）参与肿瘤微环境的调控。外泌体不仅与肺恶性肿瘤微环境形成密切相关，同时其可增加肺癌细胞侵袭与转移能力，对肿瘤免疫抑制有介导作用，还参与肺癌患者接受放化疗后耐药的机制中。本文就CAFs来源相关外泌体在肺癌中的研究现状和进展做一综述。 】 【中文关键词：肿瘤微环境；癌相关成纤维细胞；外泌体；肺肿瘤】.
Keywords: Cancer-associated fibroblasts; Exosomes; Lung neoplasms; Tumor microenvironment.