Senescence in tissue samples of humans with age-related diseases: A systematic review

Camilla S L Tuttle; Suzanne W M Luesken; Mariette E C Waaijer; Andrea B Maier

doi:10.1016/j.arr.2021.101334

Senescence in tissue samples of humans with age-related diseases: A systematic review

Ageing Res Rev. 2021 Jul:68:101334. doi: 10.1016/j.arr.2021.101334. Epub 2021 Apr 2.

Authors

Camilla S L Tuttle¹, Suzanne W M Luesken², Mariette E C Waaijer³, Andrea B Maier⁴

Affiliations

¹ Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, 300 Grattan Street, Parkville, 3050, Victoria, Australia; Centre for Quantitative Neuroimaging, Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Victoria, Australia.
² Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, 300 Grattan Street, Parkville, 3050, Victoria, Australia.
³ Department of Internal Medicine, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands.
⁴ Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, 300 Grattan Street, Parkville, 3050, Victoria, Australia; Department of Human Movement Sciences, @AgeAmsterdam, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Van der Boechorststraat 7, 1081 BT Amsterdam, the Netherlands; Healthy Longevity Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Centre for Healthy Longevity, National University Health System, Singapore. Electronic address: a.b.maier@vu.nl.

PMID: 33819674
DOI: 10.1016/j.arr.2021.101334

Abstract

Background: Higher numbers of senescent cells have been implicated in age-related disease pathologies. However, whether different diseases have different senescent phenotypes is unknown. Here we provide a systematic overview of the current available evidence of senescent cells in age-related diseases pathologies in humans and the markers currently used to detect senescence levels in humans.

Methods: PubMed, Web of Science and EMBASE were systematically searched from inception to the 29^th of September 2019, using keywords related to 'senescence', 'age-related diseases' and 'biopsies'.

Results: In total 12,590 articles were retrieved of which 103 articles were included in this review. The role of senescence in age-related disease has been assessed in 9 different human organ system and 27 different age-related diseases of which heart (27/103) and the respiratory systems (18/103) are the most investigated. Overall, 27 different markers of senescence have been used to determine cellular senescence and the cell cycle regulator p16^ink4a is most often used (23/27 age-related pathologies).

Conclusion: This review demonstrates that a higher expression of senescence markers are observed within disease pathologies. However, not all markers to detect senescence have been assessed in all tissue types.

Keywords: Age-related disease; Ageing; Cellular senescence; Humans; Pathology.

Publication types

Research Support, Non-U.S. Gov't
Review
Systematic Review

MeSH terms

Aging
Biomarkers
Cellular Senescence*
Cyclin-Dependent Kinase Inhibitor p16* / genetics
Humans
Phenotype

Substances

Biomarkers
Cyclin-Dependent Kinase Inhibitor p16