Restoring the endothelial barrier function in the elderly

Nektarios Barabutis; Mohammad S Akhter; Khadeja-Tul Kubra; Mohammad A Uddin

doi:10.1016/j.mad.2021.111479

Restoring the endothelial barrier function in the elderly

Mech Ageing Dev. 2021 Jun:196:111479. doi: 10.1016/j.mad.2021.111479. Epub 2021 Apr 2.

Authors

Nektarios Barabutis¹, Mohammad S Akhter², Khadeja-Tul Kubra², Mohammad A Uddin²

Affiliations

¹ School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA. Electronic address: barabutis@ulm.edu.
² School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA.

Abstract

Endothelial barrier dysfunction in the elderly has been associated with severe disorders, including acute respiratory distress syndrome, sepsis and COVID-19. Herein we deliver an opinion regarding the development of alternative therapeutic avenues to counteract the pathogenesis of the corresponding diseases.

Keywords: Acute lung injury; Acute respiratory distress syndrome; Inflammation.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aged
COVID-19 / metabolism*
COVID-19 / pathology
Endothelial Cells / metabolism*
Endothelial Cells / pathology
Humans
SARS-CoV-2 / metabolism*