Hydrogels are an important class of soft materials that find use in bioactive agent delivery. Because of their high water content, hydrogels generally show poor mechanical strength. Long-term wear and tear in physiological conditions may lead to damage in the hydrogel structure during the delivery of bioactive agents. This results in burst and uncontrolled agent release. One strategy to solve this problem is to incorporate self-healing properties into a hydrogel so that the hydrogel can heal fractures automatically to restore original mechanical properties. The objectives of this article are to revisit the latest advances in the design of self-healing hydrogel-based carriers and to offer insights into further research to translate these carriers from the laboratory to real applications.
Keywords: bioactive agent delivery; hydrogels; self-healing; soft materials; sustained release.