Pituitary neuropeptides and B lymphocyte function

Ann L Benko; A Dale Wright; Teresa Sunyer; William J Kovacs; Nancy J Olsen

doi:10.1111/sji.13041

Pituitary neuropeptides and B lymphocyte function

Scand J Immunol. 2021 Aug;94(2):e13041. doi: 10.1111/sji.13041. Epub 2021 Apr 4.

Authors

Ann L Benko¹, A Dale Wright², Teresa Sunyer², William J Kovacs³, Nancy J Olsen¹

Affiliations

¹ Division of Rheumatology, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.
² Mallinckrodt Pharmaceuticals, Hazelwood, MO, USA.
³ Division of Endocrinology, Diabetes, and Metabolism, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.

PMID: 33817820
DOI: 10.1111/sji.13041

Abstract

This review discusses the accumulated evidence that pro-opiomelanocortin (POMC) gene products as well as other pituitary neuropeptides derived from related genes (Proenkephalin, PENK; Prodynorphin, PDYN, and Pronociceptin, PNOC) can exert direct effects on B lymphocytes to modulate their functions. We also review the available data on receptor systems that might be involved in the transmission of such hormonal signals to B cells.

Keywords: B cells; antibodies/immunoglobulins; human.

Publication types

Review

MeSH terms

Animals
B-Lymphocytes / metabolism*
Enkephalins / metabolism
Humans
Neuropeptides / metabolism*
Pro-Opiomelanocortin / metabolism
Protein Precursors / metabolism
Receptors, Opioid / metabolism

Substances

Enkephalins
Neuropeptides
Protein Precursors
Receptors, Opioid
proenkephalin
pronociceptin
Pro-Opiomelanocortin
preproenkephalin

Grants and funding

Mallinckrodt Pharmaceuticals