Analysis of SEC24D Gene in Breast Cancer Based on UALCAN Database

Zhi Liu; Jing Zhou; Zhibao Wang; Zhiqiang Zhou

doi:10.1515/biol-2019-0080

Analysis of SEC24D Gene in Breast Cancer Based on UALCAN Database

Open Life Sci. 2019 Dec 31:14:707-711. doi: 10.1515/biol-2019-0080. eCollection 2019 Jan.

Authors

Zhi Liu¹, Jing Zhou², Zhibao Wang³, Zhiqiang Zhou³

Affiliations

¹ Department of Radiology, Affiliated Hospital of North China University of Science and Technology, Tangshan 063000, P.R. China.
² Department of Endocrinology, Tangshan Hospital of Traditional Chinese Medicine, Tangshan 063000, P.R. China.
³ Department of Radiology, The No.2 Hospital of Baoding, Baoding 071051, P.R. China.

Abstract

Objective: To analyze the expression and its clinical significance of the SEC24D gene in breast cancer.

Methods: The dataset of breast cancer were searched in the UALCAN database, and the data obtained were mined and combined with literature analysis.

Results: The mRNA expression of the SEC24D gene in breast cancer tissues was significantly higher than that of breast normal tissues from the UALCAN database (P < 0.05). The promoter methylation levels of the SEC24D gene in breast cancer tissues were lower than that of breast normal tissues (P < 0.05). Survival analysis showed that the relapse-free survival of breast cancer patients with a higher expression of SEC24D gene was significantly worse than those patients with a lower expression of SEC24D (P < 0.05).

Conclusion: The SEC24D gene has a high expression in breast cancer tissues and its expression level was related to the prognosis of breast cancer patients.

Keywords: Breast cancer; Prognosis; SEC24D; UALCAN.