Effects of Huaiqihuang Granules Adjuvant Therapy in Children with Primary Nephrotic Syndrome

Ping Zhou; Qiong Xiao; Lan Chen; Zhi-Jie Zou; Yu-Qing Wang; Lin Zhu; Hai-Yan Yu; Cheng-Guang Zhao; Yu-Bin Wu; Xuan-Yi Du

doi:10.1515/biol-2019-0058

Effects of Huaiqihuang Granules Adjuvant Therapy in Children with Primary Nephrotic Syndrome

Open Life Sci. 2019 Dec 31:14:519-527. doi: 10.1515/biol-2019-0058. eCollection 2019 Jan.

Authors

Ping Zhou¹, Qiong Xiao², Lan Chen¹, Zhi-Jie Zou¹, Yu-Qing Wang¹, Lin Zhu¹, Hai-Yan Yu¹, Cheng-Guang Zhao³, Yu-Bin Wu³, Xuan-Yi Du⁴

Affiliations

¹ Department of pediatrics, 2nd Affiliated Hospital of Harbin Medical University,Harbin, Heilongjiang province, 150086,China.
² Department of Infections Diseases, Children's Hospital of Harbin,Harbin city, Heilongjiang province, 150010,China.
³ Pediatric kidney rheumatology, Shengjing Hospital Affiliated of China Medical University, Shenyang, 110004, China.
⁴ Department of Nephrology, 2nd Affiliated Hospital of Harbin Medical University, No.246 of Xuefu street, Nangang District, Harbin, 150086, China.

Abstract

Objective: This study aims to observe the curative effect of Huaiqihuang Granules adjuvant therapy on primary nephrotic syndrome (PNS).

Methods: A total of 112 children with PNS were randomly divided into three groups, and changes in serum inflammatory cytokines, interleukin, lymphocyte subsets and immunoglobulin were observed.

Results: Before treatment, IL-18, TNF-α, CD8+ increased, while IL-10, CD4+, NK cells, IgA, IgG and Foxp3+Treg cells decreased. After Huaiqihuang Granules treatment, IL-18, TNF-α, CD8+ decreased, while IL-10, CD4+, NK cells, IgA, IgG and Foxp3+Treg cells increased.

Conclusion: Functions of cell immunity and humoral immunity in PNS patients before treatment were suppressed and disordered. Huaiqihuang granules can play a role in immunoregulation, with slight side reactions.

Keywords: Huaiqihuang Granules; Primary nephrotic syndrome; immune function; interleukin; lymphocyte subsets.