The Prediction of Cardiac Events in Patients with Acute ST Segment Elevation Myocardial Infarction: A Meta-analysis of Serum Uric Acid

Hailong Wang; Jianjun Yang; Jiang Sao; Jianming Zhang; Xiaohua Pang

doi:10.1515/biol-2018-0050

The Prediction of Cardiac Events in Patients with Acute ST Segment Elevation Myocardial Infarction: A Meta-analysis of Serum Uric Acid

Open Life Sci. 2018 Nov 9:13:413-421. doi: 10.1515/biol-2018-0050. eCollection 2018 Jan.

Authors

Hailong Wang¹, Jianjun Yang¹, Jiang Sao¹, Jianming Zhang¹, Xiaohua Pang¹

Affiliation

¹ Department of Cardiology, Heart center, Chongqing Three Gorges Central Hospital, Wanzhou, Chongqing, China.

Abstract

Objective: The current study aimed to explore the predictive ability of serum uric acid (SUA) in patients suffering from acute ST segment elevation myocardial infarction (STEMI).

Method: PubMed, EMBASE, Cochrane Library, and Medline databases were systematically searched from their respective inceptions to February 2018. Systematic analysis and random-effects meta-analysis of prognostic effects were performed to evaluate STEMI outcomes [i.e., in-hospital mortality, one-year mortality, in-hospital Major Adverse Cardiovascular Events (MACE)] in relation to SUA.

Results: A total of 12 studies (containing 7,735 patients with acute STEMI) were identified (5,562 low SUA patients and 3,173 high SUA patients). Systematic analysis of these studies showed that high SUA patients exhibited a higher incidence of in-hospital MACE (OR, 2.30; P < 0.00001), in-hospital mortality (OR, 3.03; P < 0.0001), and one-year mortality (OR, 2.58; P < 0.00001), compared with low SUA patients.

Conclusions: Acute STEMI patients with high SUA exhibited an elevated incidence rate of in-hospital MACE, in-hospital mortality, and one-year mortality. Further randomized controlled trials will be needed to verify these results.

Keywords: Major Adverse Cardiovascular Events (MACE); ST segment elevation myocardial infarction (STEMI); meta–analysis; mortality; serum uric acid (SUA).