Limited detection power has been a bottleneck for subject-specific functional MRI (fMRI) studies, however the higher signal-to-noise ratio afforded by ultra-high magnetic fields (≥ 7 Tesla) provides levels of sensitivity and resolution needed to study individual subjects. What may be surprising is that higher imaging resolution may provide both higher specificity and sensitivity due to reductions in partial volume effects and reduced physiological noise. However, challenges remain to ensure high data quality and to reduce variability in ultra-high field fMRI. We discuss session-specific biases including those caused by factors related to instrumentation, anatomy, and physiology-which can translate into variability across sessions-and how to minimize these to help ultra-high field fMRI reach its full potential for individual-focused studies.
Keywords: BOLD fMRI; MRI physics; high-resolution fMRI; parallel imaging; precision fMRI; single-subject fMRI; ultra-high field.