The Role of the Signaling Pathways Involved in the Effects of Hydrogen Sulfide on Endoplasmic Reticulum Stress

Shizhen Zhao; Xinping Li; Ping Lu; Xiaotian Li; Mingfei Sun; Honggang Wang

doi:10.3389/fcell.2021.646723

The Role of the Signaling Pathways Involved in the Effects of Hydrogen Sulfide on Endoplasmic Reticulum Stress

Front Cell Dev Biol. 2021 Mar 19:9:646723. doi: 10.3389/fcell.2021.646723. eCollection 2021.

Authors

Shizhen Zhao¹, Xinping Li¹, Ping Lu², Xiaotian Li¹, Mingfei Sun³, Honggang Wang¹

Affiliations

¹ Institute of Biomedical Informatics, Bioinformatics Center, School of Basic Medical Sciences, Henan University, Kaifeng, China.
² Key Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng, China.
³ The First Affiliated Hospital of Henan University, Kaifeng, China.

Abstract

Endoplasmic reticulum (ER) is a kind of organelle with multiple functions including protein synthesis, modification and folding, calcium storage, and lipid synthesis. Under stress conditions, ER homeostasis is disrupted, which is defined as ER stress (ERS). The accumulation of unfolded proteins in the ER triggers a stable signaling network named unfolded protein response (UPR). Hydrogen sulfide is an important signal molecule regulating various physiological and pathological processes. Recent studies have shown that H₂S plays an important role in many diseases by affecting ERS, but its mechanism, especially the signaling pathways, is not fully understood. Therefore, in this review, we summarize the recent studies about the signaling pathways involved in the effects of H₂S on ERS in diseases to provide theoretical reference for the related in-depth researches.

Keywords: disease treatment; endoplasmic reticulum stress; hydrogen sulfide; signaling pathway; unfolded protein response.

Publication types

Review