Platelet Distribution Width and Mortality in Hemodialysis Patients

Wang Ruiyan; Xu Bin; Dong Jianhua; Zhou Lei; Gong Dehua; Zheng Tang

doi:10.1155/2021/6633845

Platelet Distribution Width and Mortality in Hemodialysis Patients

Evid Based Complement Alternat Med. 2021 Mar 15:2021:6633845. doi: 10.1155/2021/6633845. eCollection 2021.

Authors

Wang Ruiyan^{1

2}, Xu Bin³, Dong Jianhua³, Zhou Lei³, Gong Dehua³, Zheng Tang^{1

3}

Affiliations

¹ Jinling Hospital Department of Nephrology, Nanjing Medical University, Nanjing, China.
² Department of Nephrology, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
³ Jinling Hospital Research Institute of Kidney Disease, Nanjing University School of Medicine, Nanjing, China.

Abstract

Objectives: The association between platelet distribution width (PDW) and mortality in hemodialysis (HD) patients has received little attention.

Methods: We retrospectively enrolled HD patients in a single center from January 1, 2008, to December 30, 2011. The primary and secondary endpoints were all-cause and cardiovascular mortality, respectively. The association between PDW and mortality was estimated by Cox regression model.

Results: Of 496 patients, the mean age was 52.5 ± 16.6 years, and the Charlson comorbidity index was 4.39 ± 1.71. During the follow-up period of 48.8 ± 6.7 months, 145 patients (29.2%) died, including 74 (14.9%) cardiovascular deaths. 258 (52.0%) with PDW < 16.31% were in the low group and 238 (48.0%) in those with PDW ≥ 16.31% according to cut-off for all-cause mortality by receiving-operator characteristics. After adjusting for confounding factors, high PDW values were independently associated with higher risk of all-cause (hazards ratio (HR) = 1.49, 95% confidence interval (CI) 1.15-6.82) and cardiovascular deaths (HR = 2.26, 95% CI 1.44-3.63) in HD patients. When comparing with quartile 1 of PDW, quartile 4 of PDW was independently associated with a higher risk of all-cause (HR = 1.59, 95% CI 1.18-5.30) and cardiovascular deaths (HR = 2.71, 95% CI 1.49-3.76) in HD patients.

Conclusions: Baseline PDW was independently associated with all-cause and cardiovascular mortality in HD patients.