Upregulation of Piezo1 (Piezo Type Mechanosensitive Ion Channel Component 1) Enhances the Intracellular Free Calcium in Pulmonary Arterial Smooth Muscle Cells From Idiopathic Pulmonary Arterial Hypertension Patients

Hypertension. 2021 Jun;77(6):1974-1989. doi: 10.1161/HYPERTENSIONAHA.120.16629. Epub 2021 Apr 5.

¹ State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, China (J. Liao, W.L., Yuqin Chen, C.Z., X. Luo, Z.L., J.C., S.L., H.Y., Yilin Chen, H.F., D.Z., X.C., Z.Z., Q.Y., X. Liu, H.T., N.Z., K.Y., J.W.).
² State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.D.).
³ Department of Medicine, University of California, San Diego, La Jolla (J.C., A.M., J.X.-J.Y., J.W.).
⁴ Lingnan Medical Research Center, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, China (J. Li).

Abstract

[Figure: see text].

Keywords: calcium; endothelium; homeostasis; muscle cells; pulmonary arterial hypertension.