Microtubule sliding is an underappreciated mechanism that contributes to the establishment, organization, preservation, and plasticity of neuronal microtubule arrays. Powered by molecular motor proteins and regulated in part by static crosslinker proteins, microtubule sliding is the movement of microtubules relative to other microtubules or to non-microtubule structures such as the actin cytoskeleton. In addition to other important functions, microtubule sliding significantly contributes to the establishment and maintenance of microtubule polarity patterns in different regions of the neuron. The purpose of this article is to review the state of knowledge on microtubule sliding in the neuron, with emphasis on its mechanistic underpinnings as well as its functional significance.
Keywords: Axon; Cytoplasmic dynein; KIFC1; Kinesin-1; Microtubule; Microtubule crosslinking; Microtubule polarity orientation; Microtubule polarity sorting; Microtubule sliding; Microtubule transport; TRIM46.
Copyright © 2021 Elsevier B.V. All rights reserved.