Mesenchymal stem cells (MSC) are capable of supporting hematopoiesis, regulating immune responses, promoting tissue regeneration and homing to damaged tissues, but their efficacy cannot completely exploit due to various factors. Studies in recent years have shown that the biological characteristics of mesenchymal stem cells have plasticity. Researchers can enhance the biological performance of MSC by pretreatment with hypoxia, bioactive molecules, genetic modification, and mechanical stimulation, as well as adjusting MSC transplantation strategies, which has great significance for promoting the transformation of MSC. Therefore, in this review, the recent research advances in the plasticity of the biological characteristics of MSC are summarized briefly.
题目: 间充质干细胞生物学特性的可塑性研究进展.
摘要: 间充质干细胞（MSC）同时具有造血支持、免疫调节、组织修复再生和归巢等特性，但由于各种因素常常不能充分发挥其效能。近期研究显示，MSC的生物学特性具有可塑性。研究人员通过对MSC进行低氧预处理、生物活性分子预处理、基因修饰预处理和力学刺激预处理以及调整MSC的移植策略，使其生物效能增强，该方向对于推动MSC的转化应用具有重要意义。基于此，本文就MSC生物学特性的可塑性研究最新进展作一综述.