Abstract
In rats, the pharmacokinetics of 14C-ambazone after i.v. and oral administration was studied. The results demonstrate that the compound is incompletely absorbed from the gastrointestinal tract, penetrates rapidly and to a high degree into various tissues and is preferentially eliminated via the kidneys. After i.v. administration of 50 mg/kg b.m. disposition half-life in whole blood is about 6-7 h. The extent of absorption from the gastrointestinal tract is about 40%.
MeSH terms
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Administration, Oral
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Animals
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / pharmacokinetics*
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Antineoplastic Agents / urine
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Bile / metabolism
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Feces / analysis
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Injections, Intravenous
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Male
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Mitoguazone / administration & dosage
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Mitoguazone / analogs & derivatives*
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Mitoguazone / pharmacokinetics
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Mitoguazone / urine
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Rats
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Rats, Inbred Strains
Substances
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Antineoplastic Agents
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1,4-benzoquinone guanylhydrazone thiosemicarbazone
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Mitoguazone