Abstract
Marine invertebrates have been reported to be an excellent resource of many novel bioactive compounds. Studies reported that Indonesia has remarkable yet underexplored marine natural products, with a high chemical diversity and a broad spectrum of biological activities. This review discusses recent updates on the exploration of marine natural products from Indonesian marine invertebrates (i.e., sponges, tunicates, and soft corals) throughout 2007-2020. This paper summarizes the structural diversity and biological function of the bioactive compounds isolated from Indonesian marine invertebrates as antimicrobial, antifungal, anticancer, and antiviral, while also presenting the opportunity for further investigation of novel compounds derived from Indonesian marine invertebrates.
Keywords:
Indonesia; biodiversity; biological activity; marine invertebrates; marine natural product; soft corals; sponges; tunicates.
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification
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Alkaloids / pharmacology
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Animals
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Anthozoa / chemistry*
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Anthozoa / metabolism
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Anti-Infective Agents / chemistry*
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Anti-Infective Agents / isolation & purification
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Anti-Infective Agents / pharmacology
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Aquatic Organisms
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Biological Products / chemistry*
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Biological Products / isolation & purification
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Biological Products / pharmacology
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Humans
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Peptides / chemistry
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Peptides / isolation & purification
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Peptides / pharmacology
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Polyketides / chemistry
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Polyketides / isolation & purification
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Polyketides / pharmacology
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Porifera / chemistry*
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Porifera / metabolism
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Secondary Metabolism / physiology
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Structure-Activity Relationship
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Terpenes / chemistry
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Terpenes / isolation & purification
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Terpenes / pharmacology
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Urochordata / chemistry*
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Urochordata / metabolism
Substances
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Alkaloids
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Anti-Infective Agents
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Antineoplastic Agents
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Biological Products
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Peptides
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Polyketides
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Terpenes