The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives

François Pognan; Thomas Steger-Hartmann; Carlos Díaz; Niklas Blomberg; Frank Bringezu; Katharine Briggs; Giulia Callegaro; Salvador Capella-Gutierrez; Emilio Centeno; Javier Corvi; Philip Drew; William C Drewe; José M Fernández; Laura I Furlong; Emre Guney; Jan A Kors; Miguel Angel Mayer; Manuel Pastor; Janet Piñero; Juan Manuel Ramírez-Anguita; Francesco Ronzano; Philip Rowell; Josep Saüch-Pitarch; Alfonso Valencia; Bob van de Water; Johan van der Lei; Erik van Mulligen; Ferran Sanz

doi:10.3390/ph14030237

The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives

Pharmaceuticals (Basel). 2021 Mar 8;14(3):237. doi: 10.3390/ph14030237.

Authors

François Pognan¹, Thomas Steger-Hartmann², Carlos Díaz³, Niklas Blomberg⁴, Frank Bringezu⁵, Katharine Briggs⁶, Giulia Callegaro⁷, Salvador Capella-Gutierrez⁸, Emilio Centeno⁹, Javier Corvi⁸, Philip Drew¹⁰, William C Drewe⁶, José M Fernández⁸, Laura I Furlong^{9

11}, Emre Guney⁹, Jan A Kors¹², Miguel Angel Mayer⁹, Manuel Pastor⁹, Janet Piñero⁹, Juan Manuel Ramírez-Anguita⁹, Francesco Ronzano⁹, Philip Rowell⁶, Josep Saüch-Pitarch⁹, Alfonso Valencia^{8

13}, Bob van de Water⁷, Johan van der Lei¹², Erik van Mulligen¹², Ferran Sanz⁹

Affiliations

¹ Preclinical Safety/Translational Medicine, Novartis, 4057 Basel, Switzerland.
² Pharmaceuticals, Investigational Toxicology, Bayer AG, 13342 Berlin, Germany.
³ Synapse Research Managers SL, 28006 Madrid, Spain.
⁴ ELIXIR, Hinxton, Cambridgeshire CB10 1SD, UK.
⁵ Chemical & Preclinical Safety, Merck Healthcare KGaA, 64293 Darmstadt, Germany.
⁶ Lhasa Limited, Leeds LS11 5PS, UK.
⁷ Leiden Academic Centre for Drug Research (LACDR), Leiden University, 2300 RA Leiden, The Netherlands.
⁸ Barcelona Supercomputing Center (BSC), 08034 Barcelona, Spain.
⁹ GRIB, Hospital del Mar Institute of Medical Research (IMIM), DCEXS, Pompeu Fabra University (UPF), 08003 Barcelona, Spain.
¹⁰ PDS Consultants, Leicester LE1 5XY, UK.
¹¹ MedBioinformatics Solutions SL, 08018 Barcelona, Spain.
¹² Department of Medical Informatics, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
¹³ Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain.

Abstract

eTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI), which aims at developing integrated databases and computational tools (the eTRANSAFE ToxHub) that support the translational safety assessment of new drugs by using legacy data provided by the pharmaceutical companies that participate in the project. The project objectives include the development of databases containing preclinical and clinical data, computational systems for translational analysis including tools for data query, analysis and visualization, as well as computational models to explain and predict drug safety events.

Keywords: data mining; data sharing; drug safety; integrative knowledge management; predictive modelling; read across; toxicology; translational safety assessment.