Alginate enriched with phytic acid for hydrogels preparation

Int J Biol Macromol. 2021 Jun 30:181:561-571. doi: 10.1016/j.ijbiomac.2021.03.164. Epub 2021 Mar 30.

Abstract

Alginate hydrogels are extremely versatile and flexible biomaterials, with an enormous potential for bio-applications use. Their similarity with extracellular matrix is a key factor in their performance for cell and tissue regeneration. In this study superabsorbent high porous hydrogels based on sodium alginate physical crosslinked with a natural crosslinker compound namely phytic acid were prepared and evaluated from the viewpoint of their specific properties. The resulting hydrogels obtained with different ratios between alginate and phytic acid were characterized by Fourier transform infrared spectroscopy technique, scanning electron microscopy, XRD measurements, swelling tests in physiological environment, and thermal analysis by using a simultaneous TG/FT-IR/MS system. There are put into evidence the differences in physico-chemical properties of the hydrogels in relation with their composition, which endows them tunable properties and versatility.

Keywords: Alginate; Bio-crosslinker; Hydrogel.

MeSH terms

  • Alginates / chemistry*
  • Hydrogels / chemical synthesis*
  • Hydrogels / chemistry
  • Mass Spectrometry
  • Phytic Acid / chemistry*
  • Principal Component Analysis
  • Spectroscopy, Fourier Transform Infrared
  • Spectroscopy, Near-Infrared
  • Temperature
  • Thermogravimetry
  • X-Ray Diffraction

Substances

  • Alginates
  • Hydrogels
  • Phytic Acid