Metabolomic mechanisms of short chain chlorinated paraffins toxicity in rats

Lixin Yang; Yinping Liu; Ze Cui; Yongmao Zhang; Jianbo Zhang; Kaoqi Lian

doi:10.1016/j.envres.2021.111060

Metabolomic mechanisms of short chain chlorinated paraffins toxicity in rats

Environ Res. 2021 Jun:197:111060. doi: 10.1016/j.envres.2021.111060. Epub 2021 Mar 31.

Authors

Lixin Yang¹, Yinping Liu², Ze Cui², Yongmao Zhang³, Jianbo Zhang⁴, Kaoqi Lian⁵

Affiliations

¹ State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing, 100871, China; Hebei Centre for Disease Control and Prevention, Shijiazhuang, 050021, China.
² Hebei Centre for Disease Control and Prevention, Shijiazhuang, 050021, China.
³ State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing, 100871, China.
⁴ State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing, 100871, China. Electronic address: zhangjb@pku.edu.cn.
⁵ School of Public Health, Hebei Medical University, Shijiazhuang, Hebei, 050017, China; Hebei Province Key Laboratory of Environment and Human Health, Hebei Medical University, Shijiazhuang, 050017, China. Electronic address: liankq@hebmu.edu.cn.

PMID: 33798518
DOI: 10.1016/j.envres.2021.111060

Abstract

Short chain chlorinated paraffins (SCCPs) have received increased interest worldwide since they were added to the list of controlled POPs in Annex A of the Stockholm Convention in 2017. Although many toxicological studies have already shown that SCCPs are hepatotoxic, nephrotoxic, and thyrotoxic to rodents, there have been few studies to date that have characterized changes in the metabolic pathways targeted by SCCPs. In this study, a UPLC-Q-TOF-MS based plasma metabolomics approach was used to investigate the toxicity of SCCPs in rats. Liver and kidney injury occurred rapidly after high-dose SCCP exposure, and the most relevant pathways affected were energy metabolism, amino acid metabolism, glycerophospholipid metabolism, nucleotide metabolism, and vitamin B metabolism. Exposure to SCCPs inhibited the tricarboxylic acid cycle and accelerated degradation. Fluctuating levels of phospholipids and nucleotides may have contributed to the neurotoxicity of SCCPs. In addition, the down regulation of folic acid induced by SCCPs may have led to malformations during the early development of laboratory animals. These results suggested that high exposure levels of SCCPs may have serious health risks and more research is needed to assess the health status of relevant occupational groups.

Keywords: Metabonomics; Short chain chlorinated paraffins; Toxicity; UPLC-Q-TOF.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
China
Environmental Monitoring
Hydrocarbons, Chlorinated* / analysis
Hydrocarbons, Chlorinated* / toxicity
Lipid Metabolism
Metabolic Networks and Pathways
Metabolomics
Paraffin* / analysis
Paraffin* / toxicity
Rats

Substances

Hydrocarbons, Chlorinated
Paraffin