Association between short-term ambient air pollution and outpatient visits of anxiety: A hospital-based study in northwestern China

Abstract

Anxiety, a common and devastating mental disorder, has raised widespread interests. The impacts of air pollution on physical health are well known, whereas few studies have explored the association of atmospheric pollution, especially short-term air pollution exposure, with the risk of anxiety disorders. In addition, there are increasing concerns in emerging evidence supporting a possible etiological link. Therefore, our aim was to evaluate the relationship between short-term exposure to atmospheric pollutants and anxiety outpatient visits in Xi'an, a city of northwestern China and a metropolis with relatively heavy air pollution. We collected the data of both daily outpatient visits and daily air pollution (SO₂, NO₂, and PM₁₀) between January 1, 2010 and January 31, 2016 (2222 days). To clarify the association between short-term ambient atmospheric pollution exposure and anxiety outpatient visits, an over-dispersed Poisson generalized additive model was applied by adjusting the day of the week and weather conditions (including temperature, humidity, sunlight hours, and rainfalls). Positive association between gaseous air pollutants (SO₂ and NO₂) and anxiety daily outpatient visits was observed. Moreover, the largest estimated values of both SO₂ and NO₂ were evidence at lag 03 (4-day moving average lag), with 10 μg/m³ increase corresponded to the increase of outpatient anxiety visits at 4.11% (95% CI: 2.15%, 6.06%) for SO₂ and 3.97% (95% CI: 1.90%, 6.06%) for NO₂. However, there was no differences in susceptibility to air pollutants between different genders as well as different ages. Taken together, short-term exposure to ambient air pollutants, especially gaseous air pollutants (NO₂ and SO₂), can be related to higher risk of anxiety outpatient visits.

Keywords: Anxiety; Outpatient visits; Short-term ambient air pollution; Time-series analysis.