Tête-à-tête with CtBP dimers

Ana-Maria Raicu; Kalynn M Bird; David N Arnosti

doi:10.1016/j.str.2021.03.006

Tête-à-tête with CtBP dimers

Structure. 2021 Apr 1;29(4):307-309. doi: 10.1016/j.str.2021.03.006.

Authors

Ana-Maria Raicu¹, Kalynn M Bird², David N Arnosti³

Affiliations

¹ Cell and Molecular Biology Graduate Program, Michigan State University, East Lansing, MI, USA.
² Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.
³ Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA. Electronic address: arnosti@msu.edu.

Abstract

Jecrois et al. (2020) use cryoelectron microscopy to illuminate the tetrameric conformation of the CtBP2 transcriptional corepressor, a protein frequently overexpressed in human cancers. The in vivo functional characterization of tetramer-destabilizing mutants indicates that tetramerization is a physiologically important process, critical for CtBP control of gene regulation and cell migration.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Alcohol Oxidoreductases* / genetics
Cell Movement
Co-Repressor Proteins
Cryoelectron Microscopy
DNA-Binding Proteins* / genetics
Humans
Transcription Factors

Substances

Co-Repressor Proteins
DNA-Binding Proteins
Transcription Factors
Alcohol Oxidoreductases
CTBP2 protein, human

Grants and funding

R01 GM124137/GM/NIGMS NIH HHS/United States