Harnessing developmental plasticity to pattern kidney organoids

Rohan Bhattacharya; Makenzie G Bonner; Samira Musah

doi:10.1016/j.stem.2021.03.009

Harnessing developmental plasticity to pattern kidney organoids

Cell Stem Cell. 2021 Apr 1;28(4):587-589. doi: 10.1016/j.stem.2021.03.009.

Authors

Rohan Bhattacharya¹, Makenzie G Bonner², Samira Musah³

Affiliations

¹ Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, USA; Center for Biomolecular and Tissue Engineering, Duke University, Durham, NC, USA.
² Developmental and Stem Cell Biology Program, Duke University School of Medicine, Durham, NC, USA.
³ Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, USA; Center for Biomolecular and Tissue Engineering, Duke University, Durham, NC, USA; Developmental and Stem Cell Biology Program, Duke University School of Medicine, Durham, NC, USA; Department of Medicine, Division of Nephrology, Duke University School of Medicine, Durham, NC, USA. Electronic address: samira.musah@duke.edu.

PMID: 33798416
DOI: 10.1016/j.stem.2021.03.009

Abstract

Methods for deriving the ureteric epithelium (UE) in vitro could improve understanding of kidney development and patterning. In this issue of Cell Stem Cell, Howden et al. (2021) identified transcriptionally distinct cell populations in human induced pluripotent stem cell (iPSC)-derived distal nephron (DN) epithelia that were inducible to UE phenotype within kidney organoids.

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MeSH terms

Cell Differentiation
Epithelium
Humans
Induced Pluripotent Stem Cells*
Kidney
Nephrons
Organoids
Pluripotent Stem Cells*