A network map of apelin-mediated signaling

Shobha Dagamajalu; D A B Rex; Pushparani Devi Philem; Jan K Rainey; T S Keshava Prasad

doi:10.1007/s12079-021-00614-6

A network map of apelin-mediated signaling

J Cell Commun Signal. 2022 Mar;16(1):137-143. doi: 10.1007/s12079-021-00614-6. Epub 2021 Apr 2.

Authors

Shobha Dagamajalu¹, D A B Rex², Pushparani Devi Philem², Jan K Rainey³, T S Keshava Prasad⁴

Affiliations

¹ Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, 575018, India. shobha_d@yenepoya.edu.in.
² Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, 575018, India.
³ Department of Biochemistry and Molecular Biology, Department of Chemistry, and School of Biomedical Engineering, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
⁴ Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, 575018, India. keshav@yenepoya.edu.in.

Abstract

The apelin receptor (APLNR) is a class A (rhodopsin-like) G-protein coupled receptor with a wide distribution throughout the human body. Activation of the apelin/APLNR system regulates AMPK/PI3K/AKT/mTOR and RAF/ERK1/2 mediated signaling pathways. APLNR activation orchestrates several downstream signaling cascades, which play diverse roles in physiological effects, including effects upon vasoconstriction, heart muscle contractility, energy metabolism regulation, and fluid homeostasis angiogenesis. We consolidated a network map of the APLNR signaling map owing to its biomedical importance. The curation of literature data pertaining to the APLNR system was performed manually by the NetPath criteria. The described apelin receptor signaling map comprises 35 activation/inhibition events, 38 catalysis events, 4 molecular associations, 62 gene regulation events, 113 protein expression types, and 4 protein translocation events. The APLNR signaling pathway map data is made freely accessible through the WikiPathways Database ( https://www.wikipathways.org/index.php/Pathway:WP5067 ).

Keywords: Cardiovascular disease; Inflammation; Post-translational modifications; Protein–protein interactions; Signaling pathways; WikiPathways.