Flexible optical imaging band system for the assessment of arthritis in patients with systemic lupus erythematosus

Youngwan Kim; Alessandro Marone; Wei Tang; Yevgeniya Gartshteyn; Hyun K Kim; Anca D Askanase; Ioannis Kymissis; Andreas H Hielscher

doi:10.1364/BOE.415575

Flexible optical imaging band system for the assessment of arthritis in patients with systemic lupus erythematosus

Biomed Opt Express. 2021 Feb 26;12(3):1651-1665. doi: 10.1364/BOE.415575. eCollection 2021 Mar 1.

Authors

Youngwan Kim^{1

2}, Alessandro Marone², Wei Tang³, Yevgeniya Gartshteyn³, Hyun K Kim^{2

4}, Anca D Askanase³, Ioannis Kymissis¹, Andreas H Hielscher^{2

5

6}

Affiliations

¹ Columbia University, Department of Electrical Engineering, 500 W. 120th Street, New York, NY 10027, USA.
² New York University, Department of Biomedical Engineering, Brooklyn, NY 11201, USA.
³ Columbia University Irving Medical Center, Department of Medicine-Rheumatology, 650 W. 168th Street, New York, NY 10032, USA.
⁴ Columbia University Irving Medical Center, Department of Radiology, 650 W. 168th Street, New York, NY 10032, USA.
⁵ Columbia University, Department of Biomedical Engineering, 500 W. 120th Street, New York, NY 10027, USA.
⁶ ahh4614@nyu.edu.

Abstract

We have developed a flexible optical imaging system (FOIS) to assess systemic lupus erythematosus (SLE) arthritis in the finger joints. While any part of the body can be affected, arthritis in the finger joints is one of the most common SLE manifestations. There is an unmet need for accurate, low-cost assessment of lupus arthritis that can be easily performed at every clinic visit. Current imaging methods are imprecise, expensive, and time consuming to allow for frequent monitoring. Our FOIS can be wrapped around joints, and multiple light sources and detectors gather reflected and transmitted light intensities. Using data from two SLE patients and two healthy volunteers, we demonstrate the potential of this FOIS for assessment of arthritis in SLE patients.