Dosing Patterns In Treatment of Disabling Spasticity With Intrathecal Baclofen

Rehabil Nurs. 2021 Nov-Dec;46(6):315-322. doi: 10.1097/RNJ.0000000000000323.

Abstract

Purpose: The aim of this study was to describe and analyze dosing patterns for patients with ITB treatment over time and to identify possible subgroups demonstrating diversity in patterns.

Design: A retrospective design.

Methods: For 81 patients from six different hospitals, baclofen doses from the first 2 years of treatment were identified using medical records. Line graphs of each patient's doses were analyzed and grouped based on similarities in dosing pattern.

Findings: The analyses of the dosing patterns resulted in four different subgroups classified as stable, slow increase, rapid increase, and fluctuating.

Conclusion: The results highlight the clinical challenge of predicting dose development over time.

Clinical relevance to rehabilitation nursing: This study provides rehabilitation healthcare professionals with a better understanding of intrathecal baclofen dose development. Illustrations of the four subgroups can be used as an educational tool for patients, family, and caregivers.

MeSH terms

  • Baclofen* / therapeutic use
  • Humans
  • Injections, Spinal
  • Muscle Relaxants, Central* / therapeutic use
  • Muscle Spasticity / drug therapy
  • Retrospective Studies

Substances

  • Muscle Relaxants, Central
  • Baclofen