A two-stage plasma catalyst system for high-throughput NOx removal was investigated. Herein, the plasma stage involved the large-volume plasma discharge of humidified gas and was carried out in a sandwich-type honeycomb monolith reactor consisting of a commercial honeycomb catalyst (50 mm high; 93 mm in diameter) located between two parallel perforated disks that formed the electrodes. The results demonstrated that, in the plasma stage, the reduction of NOx did not occur at room temperature; instead, NO was only oxidized to NO2 and n-heptane to oxygenated hydrocarbons. The oxidation of NO and n-heptane in the honeycomb plasma discharge state was largely affected by the humidity of the feed gas. Furthermore, the oxidation of NO to NO2 occurs preferably to that of n-heptane with a tendency of the NO oxidation to decrease with increasing feed gas humidity. The reason is that the generation of O3 decreases as the amount of water vapor in the feed gas increases. Compared to the catalyst alone, the two-stage plasma catalyst system increased NOx removal by 29% at a temperature of 200 °C and an energy density of 25 J/L.