Engineered human cardiac microtissues: The state-of-the-(he)art

Kayla Soon; Omar Mourad; Sara S Nunes

doi:10.1002/stem.3376

Engineered human cardiac microtissues: The state-of-the-(he)art

Stem Cells. 2021 Aug;39(8):1008-1016. doi: 10.1002/stem.3376. Epub 2021 Apr 15.

Authors

Kayla Soon^{1

2}, Omar Mourad^{1

2}, Sara S Nunes^{1

2

3

4}

Affiliations

¹ Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
² Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
³ Laboratory of Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
⁴ Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada.

PMID: 33786918
DOI: 10.1002/stem.3376

Abstract

Due to the integration of recent advances in stem cell biology, materials science, and engineering, the field of cardiac tissue engineering has been rapidly progressing toward developing more accurate functional 3D cardiac microtissues from human cell sources. These engineered tissues enable screening of cardiotoxic drugs, disease modeling (eg, by using cells from specific genetic backgrounds or modifying environmental conditions) and can serve as novel drug development platforms. This concise review presents the most recent advances and improvements in cardiac tissue formation, including cardiomyocyte maturation and disease modeling.

Keywords: cardiac; stem/progenitor cell; technology; tissue engineering.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Myocytes, Cardiac*
Stem Cells
Tissue Engineering*

Grants and funding

PJT153160/CIHR/Canada