Identification of a novel miR-21-3p/TGF-β signaling-driven immune escape via the MHC class I/biglycan axis in tumor cells

Clin Transl Med. 2021 Mar;11(3):e306. doi: 10.1002/ctm2.306.

Authors

Karthikeyan Subbarayan¹, Chiara Massa¹, Maria-Filothei Lazaridou¹, Kamatchi Ulagappan¹, Barbara Seliger^{1

2}

Affiliations

¹ Institute of Medical Immunology, Martin Luther University Halle-Wittenberg, Halle, Germany.
² Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biglycan / genetics*
Biglycan / immunology
Biglycan / metabolism
Breast Neoplasms / genetics*
Breast Neoplasms / immunology*
Breast Neoplasms / metabolism
Disease Models, Animal
Female
Gene Expression Regulation, Neoplastic / genetics
Genes, MHC Class I / genetics
Genes, MHC Class I / immunology
Humans
Mice
MicroRNAs / genetics*
MicroRNAs / immunology
MicroRNAs / metabolism
Signal Transduction / genetics
Signal Transduction / immunology
Transforming Growth Factor beta / genetics*
Transforming Growth Factor beta / immunology
Transforming Growth Factor beta / metabolism

Substances

BGN protein, human
Biglycan
MIRN21 microRNA, human
MicroRNAs
Transforming Growth Factor beta