NORD: NO Relaxation Delay NMR Spectroscopy

Tamás Milán Nagy; Katalin E Kövér; Ole W Sørensen

doi:10.1002/anie.202102487

NORD: NO Relaxation Delay NMR Spectroscopy

Angew Chem Int Ed Engl. 2021 Jun 7;60(24):13587-13590. doi: 10.1002/anie.202102487. Epub 2021 May 7.

Authors

Tamás Milán Nagy¹, Katalin E Kövér^{1

2}, Ole W Sørensen³

Affiliations

¹ Department of Inorganic and Analytical Chemistry, University of Debrecen, Egyetem tér 1, 4032, Debrecen, Hungary.
² MTA-DE Molecular Recognition and Interaction Research Group, University of Debrecen, Hungary.
³ Copenhagen, Denmark.

Abstract

The novel concept of NORD (NO relaxation delay) NMR spectroscopy is introduced. The idea is to design concatenated experiments in a way that the magnetization used in the first relaxes toward equilibrium during the second and vice versa, thus saving instrument time. Applications include complete well-resolved ¹ H-¹ H and ¹ H-¹³ C one-bond and long-range correlation maps of an 80 mM solution of a trisaccharide recorded in less than two minutes and hydrocortisone with extensive spectral overlap.

Keywords: H2OBC/2BOB; NMR spectroscopy; NORD; SEA XLOC/HMBC; heteronuclear correlation.

Publication types

Research Support, Non-U.S. Gov't