Interpreting and Appraising Noninferiority Trials: A Guide for Urologists and Clinicians

Félix Couture; Philippe D Violette; Philipp Dahm; Patrick O Richard

doi:10.1016/j.euf.2021.03.014

Interpreting and Appraising Noninferiority Trials: A Guide for Urologists and Clinicians

Eur Urol Focus. 2022 Mar;8(2):608-612. doi: 10.1016/j.euf.2021.03.014. Epub 2021 Mar 27.

Authors

Félix Couture¹, Philippe D Violette², Philipp Dahm³, Patrick O Richard¹

Affiliations

¹ Department of Urology, Centre Hospitalier Universitaire de Sherbrooke and Centre de Recherche du CHUS, Sherbrooke, QC, Canada.
² Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada; Department of Surgery, Woodstock General Hospital, Woodstock, ON, Canada. Electronic address: philippedenis.violette@gmail.com.
³ Urology Section, Minneapolis VA Health Care System and Department of Urology, University of Minnesota, Minneapolis, MN, USA.

PMID: 33781727
DOI: 10.1016/j.euf.2021.03.014

Abstract

Noninferiority trials are increasingly used in urology. Understanding the methodology and assessment of such trials can be challenging for clinicians. We provide an approach to interpreting the results, validity, and applicability of noninferiority studies in clinical practice.

Publication types

Editorial

MeSH terms

Humans
Urologists*
Urology*