Phenolic glycosides from the stems of Homalium stenophyllum

Shou-Yuan Wu; Meng Bai; Qi Zhou; Xu-Hua Nong; Guang-Ying Chen; Si-Yu Zhao; Chang-Ri Han; Xiao-Ping Song

doi:10.1016/S1875-5364(21)60024-9

Phenolic glycosides from the stems of Homalium stenophyllum

Chin J Nat Med. 2021 Mar;19(3):225-230. doi: 10.1016/S1875-5364(21)60024-9.

Authors

Shou-Yuan Wu¹, Meng Bai², Qi Zhou², Xu-Hua Nong², Guang-Ying Chen², Si-Yu Zhao³, Chang-Ri Han⁴, Xiao-Ping Song⁵

Affiliations

¹ Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China; Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Hainan Normal University, Haikou 571158, China; School of Chemistry and Chemical Engineering, Lingnan Normal University, Zhanjiang 524048, China.
² Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China; Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Hainan Normal University, Haikou 571158, China.
³ Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China.
⁴ Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province, Hainan Vocational University of Science and Technology, Haikou 571126, China. Electronic address: hchr116@126.com.
⁵ Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China; Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Hainan Normal University, Haikou 571158, China. Electronic address: sxp628@126.com.

PMID: 33781456
DOI: 10.1016/S1875-5364(21)60024-9

Abstract

The phytochemical investigation of the stems of Homalium stenophyllum afforded seven new phenolic glycosides (1-5 and 8-9) and two known compounds (6 and 7). Their structures were elucidated by comprehensive analyses of NMR spectroscopic, mass spectrometric data and chemical hydrolysis. Additionally, their anti-inflammatory activities against the NO production in LPS-induced macrophages were evaluated.

Keywords: Anti-inflammatory activity; Chemical hydrolysis; Homalium stenophyllum; Phenolic glycosides.

MeSH terms

Anti-Inflammatory Agents / pharmacology
Glycosides* / isolation & purification
Glycosides* / pharmacology
Macrophages / drug effects
Molecular Structure
Phenols* / isolation & purification
Phenols* / pharmacology
Phytochemicals / isolation & purification
Phytochemicals / pharmacology
Plant Stems / chemistry
Salicaceae / chemistry*

Substances

Anti-Inflammatory Agents
Glycosides
Phenols
Phytochemicals