Review and Prospects of Pathogen Detection Related to Autopsy of Coronavirus Infectious Diseases

Fa Yi Xue Za Zhi. 2021 Feb;37(1):69-76. doi: 10.12116/j.issn.1004-5619.2020.400328.
[Article in English, Chinese]

Abstract

In the past, coronavirus caused two serious human-to-human pandemics in the world, including severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). In late 2019, coronavirus disease 2019 (COVID-19) caused another major global public health event. Due to the strong infectivity of novel coronavirus, it is difficult to carry out the autopsy of related death cases widely. This paper reviews the previous status of the pathogen detection related to the autopsy of coronavirus infection diseases, and introduces the ongoing detection methods of novel coronavirus in clinical practice, in order to provide reference for the pathogen detection and study related to autopsy of COVID-19.

题目: 冠状病毒感染性疾病尸体检验相关病原学检测回顾与展望.

摘要: 冠状病毒曾经给世界带来两次严重的人类间大流行,包括严重急性呼吸综合征(severe acute respiratory syndrome,SARS)和中东呼吸综合征(Middle East respiratory syndrome,MERS),2019年岁末新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)再次引发了全球性的重大公共卫生事件。由于新型冠状病毒传染性较强,相关死亡病例的解剖工作难以广泛开展。本文对既往冠状病毒感染性疾病尸体检验相关的病原学检测情况进行回顾,介绍了临床上正在开展的新型冠状病毒的检测手段,旨在为开展COVID-19尸体检验相关的病原学检测和研究提供借鉴和参考。.

关键词: 法医病理学;冠状病毒;新型冠状病毒肺炎;严重急性呼吸综合征;中东呼吸综合征;尸体解剖;病原学检测;综述.

Keywords: forensic pathology; coronavirus; coronavirus disease 2019 (COVID-19); severe acute respiratory syndrome; Middle East respiratory syndrome; autopsy; pathogen detection; review.

Publication types

  • Review

MeSH terms

  • Autopsy
  • COVID-19*
  • Communicable Diseases*
  • Coronavirus Infections* / diagnosis
  • Humans
  • Middle East Respiratory Syndrome Coronavirus*
  • SARS-CoV-2