In vitro chronic glycation induces AGEs accumulation reducing insulin-stimulated glucose uptake and increasing GLP1R in adipocytes

Am J Physiol Endocrinol Metab. 2021 May 1;320(5):E976-E988. doi: 10.1152/ajpendo.00156.2020. Epub 2021 Mar 29.

Abstract

Intracellular AGEs accumulation increases RAGE and GLP1R and reduces glucose uptake in adipocytes.

Keywords: 3T3-L1 and human adipocytes; GLP1R; GLUT4; advanced glycation end products (AGEs); diabetes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3-L1 Cells
  • Adipocytes / drug effects*
  • Adipocytes / physiology
  • Adipogenesis / drug effects
  • Animals
  • Biological Transport / drug effects
  • Cell Differentiation / drug effects
  • Cells, Cultured
  • Glucagon-Like Peptide-1 Receptor / drug effects
  • Glucagon-Like Peptide-1 Receptor / metabolism*
  • Glucose / metabolism
  • Glucose / pharmacokinetics*
  • Glucose / pharmacology
  • Glycation End Products, Advanced / metabolism*
  • Glycosylation / drug effects
  • Humans
  • Insulin / metabolism
  • Insulin / pharmacology*
  • Mice
  • Serum Albumin, Bovine / metabolism

Substances

  • Glp1r protein, mouse
  • Glucagon-Like Peptide-1 Receptor
  • Glycation End Products, Advanced
  • Insulin
  • Serum Albumin, Bovine
  • Glucose