Long-term impacts of prenatal and infant exposure to fine particulate matter on wheezing and asthma: A systematic review and meta-analysis

Jingyi Shao; Amanda J Wheeler; Graeme R Zosky; Fay H Johnston

doi:10.1097/EE9.0000000000000042

Long-term impacts of prenatal and infant exposure to fine particulate matter on wheezing and asthma: A systematic review and meta-analysis

Environ Epidemiol. 2019 Apr 12;3(2):e042. doi: 10.1097/EE9.0000000000000042. eCollection 2019 Apr.

Authors

Jingyi Shao¹, Amanda J Wheeler^{1

2}, Graeme R Zosky^{1

3}, Fay H Johnston¹

Affiliations

¹ Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
² Behaviour, Environment and Cognition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia.
³ School of Medicine, Faculty of Health, University of Tasmania, Hobart, Tasmania, Australia.

Abstract

This systematic review aimed to summarize epidemiologic evidence regarding long-term effects of prenatal and infant particulate matter with an aerodynamic diameter less than 2.5 µm (PM_2.5) exposure on wheezing and asthma.

Methods: Epidemiologic data investigating the associations between ambient PM_2.5 exposures during prenatal or the first 2 years of life and wheezing or asthma throughout life were extracted from five databases. All included studies were assessed according to the Critical Appraisal Skills Programme checklists. We performed meta-analyses if ≥2 studies estimated the effects of continuous PM_2.5.

Results: Nine of 18 eligible studies were suitable for meta-analyses. For prenatal PM_2.5 exposure and asthma by 10 years of age (n = 4), the overall risk estimate per 10-unit increase (95% confidence interval) was 1.12 (1.00, 1.26). Although meta-analysis of prenatal exposure and wheezing by 4 years of age (n = 5) was not possible due to inconsistent exposure and outcome assessments, four studies found strong positive associations with wheeze by 2 years of age. The overall risk of developing asthma (n = 5) and wheezing (n = 3) by 8 years of age for infant PM_2.5 exposure was 1.14 (0.96, 1.35) and 1.49 (0.99, 2.26), respectively. One large high-quality study reporting risk differences not suitable for meta-analysis demonstrated significant associations between prenatal or infant PM_2.5 exposure and childhood asthma. High heterogeneity was present among studies of prenatal exposures and asthma, whereas studies of other associations showed low heterogeneity. There was insufficient evidence about susceptible subgroups.

Conclusions: The limited and inconsistent evidence is suggestive of an association between early life PM_2.5 exposure and wheezing/asthma. Large standardized studies are needed to explore the associations and identify vulnerable populations.

Keywords: Asthma; Meta-analysis; Particulate matter; Perinatal; Wheezing.

Publication types

Review