Bioactive nanotherapeutic trends to combat triple negative breast cancer

Pallabita Chowdhury; Upasana Ghosh; Kamalika Samanta; Meena Jaggi; Subhash C Chauhan; Murali M Yallapu

doi:10.1016/j.bioactmat.2021.02.037

Bioactive nanotherapeutic trends to combat triple negative breast cancer

Bioact Mater. 2021 Mar 13;6(10):3269-3287. doi: 10.1016/j.bioactmat.2021.02.037. eCollection 2021 Oct.

Authors

Pallabita Chowdhury¹, Upasana Ghosh², Kamalika Samanta¹, Meena Jaggi^{1

3

4}, Subhash C Chauhan^{1

3

4}, Murali M Yallapu^{1

3

4}

Affiliations

¹ Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.
² Department of Biomedical Engineering, School of Engineering, Rutgers University, The State University of New Jersey, Piscataway, NJ, 08854, USA.
³ Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA.
⁴ South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA.

Abstract

The management of aggressive breast cancer, particularly, triple negative breast cancer (TNBC) remains a formidable challenge, despite treatment advancement. Although newer therapies such as atezolizumab, olaparib, and sacituzumab can tackle the breast cancer prognosis and/or progression, but achieved limited survival benefit(s). The current research efforts are aimed to develop and implement strategies for improved bioavailability, targetability, reduce systemic toxicity, and enhance therapeutic outcome of FDA-approved treatment regimen. This review presents various nanoparticle technology mediated delivery of chemotherapeutic agent(s) for breast cancer treatment. This article also documents novel strategies to employ cellular and cell membrane cloaked (biomimetic) nanoparticles for effective clinical translation. These technologies offer a safe and active targeting nanomedicine for effective management of breast cancer, especially TNBC.

Keywords: Biomimetic nanoparticles; Breast cancer treatment; Chemotherapy; Membrane cloaked nanoparticles; Nanomedicine; Nanoparticles; Triple negative breast cancer.

Publication types

Review