As an adverse immune phenomenon, graft-versus-host disease often occurs after allogeneic hematopoietic stem cell transplantation. The incidence of acute and chronic graft-versus-host disease is about 40-60% and the mortality rate can reach 15%, which is a potentially fatal disease. There are rare GvHD cases involving the central nervous system. We reported a rare case of diffuse white matter changes after haploid bone marrow transplantation, summarizing its clinical manifestations and diagnosis and treatment in conjunction with the literature.
Keywords: bone marrow transplantation; central nervous system; diffuse white matter lesions; graft-versus-host disease; immunosuppression.
Copyright © 2021 Li, Zhang, Guan, Zhang, Dong, Zhao and Deng.