CA2 beyond social memory: Evidence for a fundamental role in hippocampal information processing

Andrew B Lehr; Arvind Kumar; Christian Tetzlaff; Torkel Hafting; Marianne Fyhn; Tristan M Stöber

doi:10.1016/j.neubiorev.2021.03.020

CA2 beyond social memory: Evidence for a fundamental role in hippocampal information processing

Neurosci Biobehav Rev. 2021 Jul:126:398-412. doi: 10.1016/j.neubiorev.2021.03.020. Epub 2021 Mar 26.

Authors

Andrew B Lehr¹, Arvind Kumar², Christian Tetzlaff³, Torkel Hafting⁴, Marianne Fyhn⁵, Tristan M Stöber⁶

Affiliations

¹ Department of Computational Neuroscience, University of Göttingen, Germany; Bernstein Center for Computational Neuroscience, University of Göttingen, Germany; Department of Computational Physiology, Simula Research Laboratory, Lysaker, Norway; Centre for Integrative Neuroplasticity, University of Oslo, Norway. Electronic address: andrew.lehr@phys.uni-goettingen.de.
² Department of Computational Science and Technology, KTH Royal Institute of Technology, Sweden.
³ Department of Computational Neuroscience, University of Göttingen, Germany; Bernstein Center for Computational Neuroscience, University of Göttingen, Germany.
⁴ Centre for Integrative Neuroplasticity, University of Oslo, Norway; Institute of Basic Medical Sciences, University of Oslo, Norway.
⁵ Centre for Integrative Neuroplasticity, University of Oslo, Norway; Department of Biosciences, University of Oslo, Norway.
⁶ Department of Computational Physiology, Simula Research Laboratory, Lysaker, Norway; Centre for Integrative Neuroplasticity, University of Oslo, Norway; Department of Informatics, University of Oslo, Norway. Electronic address: tristan.stoeber@posteo.net.

PMID: 33775693
DOI: 10.1016/j.neubiorev.2021.03.020

Abstract

Hippocampal region CA2 has received increased attention due to its importance in social recognition memory. While its specific function remains to be identified, there are indications that CA2 plays a major role in a variety of situations, widely extending beyond social memory. In this targeted review, we highlight lines of research which have begun to converge on a more fundamental role for CA2 in hippocampus-dependent memory processing. We discuss recent proposals that speak to the computations CA2 may perform within the hippocampal circuit.

Keywords: CA2; Hippocampus; Learning and memory; Social memory.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

CA2 Region, Hippocampal*
Cognition
Hippocampus
Humans
Memory*
Recognition, Psychology