Rapid Prototyping of Miniaturized Powder Mixing Geometries

Rasmus Svane; Troels Pedersen; Cosima Hirschberg; Jukka Rantanen

doi:10.1016/j.xphs.2021.03.019

Rapid Prototyping of Miniaturized Powder Mixing Geometries

J Pharm Sci. 2021 Jul;110(7):2625-2628. doi: 10.1016/j.xphs.2021.03.019. Epub 2021 Mar 26.

Authors

Rasmus Svane¹, Troels Pedersen¹, Cosima Hirschberg¹, Jukka Rantanen²

Affiliations

¹ Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark.
² Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark. Electronic address: jukka.rantanen@sund.ku.dk.

PMID: 33775671
DOI: 10.1016/j.xphs.2021.03.019

Abstract

Continuous manufacturing is an important element of future manufacturing solutions enabling for both high product quality and streamlined development process. The increasing possibilities with computer simulations allow for innovating novel mixing principles applicable for continuous manufacturing. However, these innovative ideas based on simulations need experimental validation. The use of rapid prototyping based on additive manufacturing opens a possibility to evaluate these ideas at a low cost. In this study, a novel powder mixing geometry was prototyped using additive manufacturing and further, interfaced with an in-line near-IR spectrometer allowing for investigating the residence time distribution (RTD) in this geometry.

Keywords: 3D printing; Continuous manufacturing; Inline monitoring; Multivariate data analysis; Process analytical technology (PAT); Residence time distribution (RTD).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Powders
Technology, Pharmaceutical*

Substances

Powders