Comprehensive Comparative Effectiveness and Safety of First-Line β-Blocker Monotherapy in Hypertensive Patients: A Large-Scale Multicenter Observational Study

Seng Chan You; Harlan M Krumholz; Marc A Suchard; Martijn J Schuemie; George Hripcsak; RuiJun Chen; Steven Shea; Jon Duke; Nicole Pratt; Christian G Reich; David Madigan; Patrick B Ryan; Rae Woong Park; Sungha Park

doi:10.1161/HYPERTENSIONAHA.120.16402

Comprehensive Comparative Effectiveness and Safety of First-Line β-Blocker Monotherapy in Hypertensive Patients: A Large-Scale Multicenter Observational Study

Hypertension. 2021 May 5;77(5):1528-1538. doi: 10.1161/HYPERTENSIONAHA.120.16402. Epub 2021 Mar 29.

Authors

Seng Chan You^{1

2}, Harlan M Krumholz^{3

4}, Marc A Suchard^{5

6}, Martijn J Schuemie^{5

7}, George Hripcsak^{8

9}, RuiJun Chen^{8

10}, Steven Shea^{8

11}, Jon Duke¹², Nicole Pratt¹³, Christian G Reich¹⁴, David Madigan¹⁵, Patrick B Ryan^{7

8}, Rae Woong Park^{1

16}, Sungha Park^{17

18}

Affiliations

¹ Department of Biomedical Informatics, Ajou University School of Medicine, Suwon, Korea (S.C.Y., R.W.P.).
² Department of Preventive Medicine and Public Health (S.C.Y.), Yonsei University College of Medicine, Seoul, Korea.
³ Yale University School of Medicine, New Haven, CT (H.M.K.).
⁴ Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, CT (H.M.K.).
⁵ Department of Biostatistics, Fielding School of Public Health (M.A.S., M.J.S.).
⁶ Department of Biomathematics, David Geffen School of Medicine at University of California, Los Angeles (M.A.S.).
⁷ Janssen Research and Development, Titusville, NJ (M.J.S., P.B.R.).
⁸ Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY (G.H., R.C., S.S., P.B.R.).
⁹ Medical Informatics Services, New York-Presbyterian Hospital (G.H.).
¹⁰ Department of Medicine, Weill Cornell Medical College, New York, NY (R.C.).
¹¹ Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY (S.S.).
¹² Georgia Tech Research Institute, Georgia Tech College of Computing, Atlanta (J.D.).
¹³ Quality Use of Medicines and Pharmacy Research Centre, Clinical and Health Sciences, University of South Australia, Adelaide (N.P.).
¹⁴ Real World Solutions, IQVIA, Cambridge, MA (C.G.R.).
¹⁵ Department of Statistics, Columbia University, New York, NY (D.M.).
¹⁶ Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, Korea (R.W.P.).
¹⁷ Division of Cardiology, Severance Cardiovascular Hospital and Integrated Research Center for Cerebrovascular and Cardiovascular Diseases (S.P.), Yonsei University College of Medicine, Seoul, Korea.
¹⁸ Section of Cardiovascular Medicine, Department of Medicine (S.P.).

Abstract

[Figure: see text].

Keywords: antihypertensive agents; atenolol; blood pressure; hypertension; stroke.

Publication types

Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't

MeSH terms

Adrenergic beta-Antagonists / adverse effects
Adrenergic beta-Antagonists / therapeutic use*
Adult
Antihypertensive Agents / adverse effects
Antihypertensive Agents / therapeutic use*
Atenolol / adverse effects
Atenolol / therapeutic use
Blood Pressure / drug effects
Carvedilol / adverse effects
Carvedilol / therapeutic use
Databases, Factual
Female
Humans
Hypertension / drug therapy*
Male
Middle Aged
Nebivolol / adverse effects
Nebivolol / therapeutic use
Treatment Outcome

Substances

Adrenergic beta-Antagonists
Antihypertensive Agents
Nebivolol
Carvedilol
Atenolol

Abstract

Publication types

MeSH terms

Substances

Grants and funding