Activation of classical and alternative complement pathways in the pathogenesis of lung injury in COVID-19

Abstract

Lung inflammation and damage is prominent in people infected with SARS-Cov-2 and a major determinant of morbidity and mortality. We report the deposition of complement components in the lungs of people who succumbed to COVID-19 consistent with the activation of the classical and the alternative pathways. Our study provides strong rationale for the expansion of trials involving the use of complement inhibitors to treat patients with COVID-19.

Keywords: COVID-19; Complement activation; Immune complexes; Lung injury; SARS-Cov-2.