Responsive optical probes for deep-tissue imaging: Photoacoustics and second near-infrared fluorescence

Fei Ding; Jing Feng; Xueli Zhang; Jielin Sun; Chunhai Fan; Zhilei Ge

doi:10.1016/j.addr.2021.03.008

Responsive optical probes for deep-tissue imaging: Photoacoustics and second near-infrared fluorescence

Adv Drug Deliv Rev. 2021 Jun:173:141-163. doi: 10.1016/j.addr.2021.03.008. Epub 2021 Mar 25.

Authors

Fei Ding¹, Jing Feng², Xueli Zhang³, Jielin Sun⁴, Chunhai Fan⁵, Zhilei Ge⁶

Affiliations

¹ School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China; Joint Research Center for Precision Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Southern Medical University Affiliated Fengxian Hospital, Shanghai 201499, China.
² Joint Research Center for Precision Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Southern Medical University Affiliated Fengxian Hospital, Shanghai 201499, China. Electronic address: fengjing8801530@163.com.
³ Joint Research Center for Precision Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Southern Medical University Affiliated Fengxian Hospital, Shanghai 201499, China.
⁴ School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.
⁵ School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address: fanchunhai@sjtu.edu.cn.
⁶ School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address: gezhilei@sjtu.edu.cn.

PMID: 33774116
DOI: 10.1016/j.addr.2021.03.008

Abstract

Optical imaging has played a vital role in development of biomedicine and image-guided theragnostic. Nevertheless, the clinical translation of optical molecular imaging for deep-tissue visualization is still limited by poor signal-to-background ratio and low penetration depth owing to light scattering and tissue autofluorescence. Hence, to facilitate precise diagnosis and accurate surgery excision in clinical practices, the responsive optical probes (ROPs) are broadly designed for specific reaction with biological analytes or disease biomarkers via chemical/physical interactions for photoacoustic and second near-infrared fluorescence (NIR-II, 900-1700 nm) fluorescence imaging. Herein, the recent advances in the development of ROPs including molecular design principles, activated mechanisms and treatment responses for photoacoustic and NIR-II fluorescence imaging are reviewed. Furthermore, the present challenges and future perspectives of ROPs for deep-tissue imaging are also discussed.

Keywords: Deep-tissue penetration; Optical imaging; Photoacoustics; Responsive optical probes; Second near-infrared fluorescence.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Fluorescence*
Fluorescent Dyes / chemistry*
Humans
Infrared Rays
Neoplasms / diagnostic imaging*
Optical Imaging*
Photoacoustic Techniques*

Substances

Fluorescent Dyes