Cerebral and splanchnic oxygenation during automated control of inspired oxygen (FiO2 ) in preterm infants

Abstract

Objectives: Our aim in this study was to assess the effect of the Predictive Intelligent Control of Oxygenation (PRICO^® ) system on cerebral (rSO₂ C) and splanchnic (rSO₂ S) oxygenation in a cohort of preterm infants with frequent desaturations.

Methods: Twenty infants with gestational age <32 weeks (n = 20) were assigned in random sequence to 12 h of automated or manual adjustment of FiO₂ . Over this period, they were studied continuously by near-infrared spectroscopy (NIRS).

Results: We found that rSO₂ C [68.0% (60.5%-74.7%) vs. 68.5% (62%-72%); p = .824] and rSO₂ S [27.0% (17.3%-45.7%) vs. 27.0% (15%-53%); p = .878] were similar during automatic and manual control of FiO₂ . Time spent with SpO₂ 90%-95% was higher during the automatic than manual control of FiO₂ , while time spent with SpO₂ <80% or >95% was lower.

Conclusions: Automated control of FiO₂ with PRICO^® system did not improve brain and splanchnic oxygenation in comparison with manual control in a cohort of preterm infants, but it significantly decreased SpO₂ fluctuations and limited the duration of both hypoxemia and hyperoxemia.

Keywords: automated control; cerebral; oxygen; oxygenation; preterm infant; splanchnic.