Rhamnogalacturonan II: Chemical Synthesis of a Substructure Including α-2,3-Linked Kdo*

Abstract

The synthesis of a fully deprotected Kdo-containing rhamnogalacturonan II pentasaccharide is described. The strategy relies on the preparation of a suitably protected homogalacturonan tetrasaccharide backbone, through a post-glycosylation oxidation approach, and its stereoselective glycosylation with a Kdo fluoride donor.

Keywords: Kdo; carbohydrates; glycosylation; plant cell wall; rhamnogalacturonan.